Psychology Honors Research

 

Cerebral Perfusion in Healthy, Normotensive Adults with Family History of Hypertension

by Erin Pomerantz

The proposed research addresses the neurological consequences of family history of hypertension (FH+). FH+ individuals are at risk for hypertension and hypertension-related cognitive impairment. Even normotensive FH+ individuals have subtle cognitive impairment. A long-term goal of the proposed research is to establish neuroimaging markers of risk for future cognitive impairment, in order to improve prevention and early treatment of hypertension-related complications.  Reduced cerebral perfusion may cause and mark risk for future hypertension-related cognitive impairment. This possibility will be explored by assessing cerebral perfusion in FH+ individuals with arterial spin labeling. It is hypothesized that at equal levels of neuropsychological performance, normotensive FH+ individuals will have lower cerebral perfusion levels than normotensive individuals without a family history of hypertension.